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A Brief Review of Short Tandem Repeat Mutation

Tipo de material: TextoTextoSeries ; Geno. Prot. Bioinfo., 5(1), p.7-14, 2007Trabajos contenidos:
  • Fan, H
  • Chu, J.Y
Tema(s): Recursos en línea: Resumen: Short tandem repeats (STRs)are short tandemly repeated DNA sequences that involve a repetitive unit of 1{6 bp. Because of their olymorphisms and high muta- tion rates, STRs are widely used in biological research. Strand-slippage replication is the predominant mutation mechanism of STRs, and the stepwise mutation model is regarded as the main mutation model. STR mutation rates can be influenced by many factors. Moreover, some trinucleotide repeats are associated with human neurodegenerative diseases. In order to deepen our knowledge of these iseases and broaden STR application, it is essential to understand the STR mutation process in detail. In this review, we focus on the current known information about STR mutation.
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Short tandem repeats (STRs)are short tandemly repeated DNA sequences that involve a repetitive unit of 1{6 bp. Because of their olymorphisms and high muta- tion rates, STRs are widely used in biological research. Strand-slippage replication is the predominant mutation mechanism of STRs, and the stepwise mutation model is regarded as the main mutation model. STR mutation rates can be influenced by many factors. Moreover, some trinucleotide repeats are associated with human neurodegenerative diseases. In order to deepen our knowledge of these iseases and broaden STR application, it is essential to understand the STR mutation process in detail. In this review, we focus on the current known information about STR mutation.

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