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N-acylated chitosan: hydrophobic matrices for controlled drug release

Tipo de material: TextoTextoSeries ; Journal of Controlled Release, 93(1), p.1-13, 2003Trabajos contenidos:
  • Le Tien, C
  • Lacroix, M
  • Ispas-Szabo, P
  • Mateescu, Ma
Tema(s): Recursos en línea: Resumen: N-acylation of chitosan with various fatty acid (C6-C16)chlorides increased its hydrophobic character and made important changes in its structural features. Unmodified chitosan exhibited a low degree of order (DO)and a weak tablet crushing strength. Chitosan acylated with a short chain length (C6)possessed similar properties, but exhibited significant swelling. Acylation with longer side chains (C8-C16)resulted in a higher DO and crushing strength but lower swelling. The best mechanical characteristics and drug release properties were found for palmitoyl chitosan (substitution degree 40-50
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Documentos solicitados Documentos solicitados CICY Documento préstamo interbibliotecario Ref1 B-10134 (Browse shelf(Opens below)) Available

N-acylation of chitosan with various fatty acid (C6-C16)chlorides increased its hydrophobic character and made important changes in its structural features. Unmodified chitosan exhibited a low degree of order (DO)and a weak tablet crushing strength. Chitosan acylated with a short chain length (C6)possessed similar properties, but exhibited significant swelling. Acylation with longer side chains (C8-C16)resulted in a higher DO and crushing strength but lower swelling. The best mechanical characteristics and drug release properties were found for palmitoyl chitosan (substitution degree 40-50

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