ER-to-Golgi transport: COP I and COP II function (Review)
ER-to-Golgi transport: COP I and COP II function (Review)
- Molecular Membrane Biology, 20(3), p.197-207, 2003 .
COP I and COP II coat proteins direct protein and membrane trafficking in between early compartments of the secretory pathway in eukaryotic cells. These coat proteins performthe dual, essential tasks of selecting appropriate cargo proteins and deforming the lipid bilayer of appropriate donor membranes into buds and vesicles. COP II proteins are required for selective export of newly synthesized proteins fromthe endoplasmic reticulum (ER). COP I proteins mediate a retrograde transport pathway that selectively recycles proteins fromthe cis-Golgi complex to the ER. Additionally, COP I coat proteins have complex functions in intra-Golgi trafficking and in maintaining the normal structure of the mammalian interphase Golgi complex.
COPI
COPII
COATOMER
GOLGI COMPLEX
COAT PROTEINS
COP I and COP II coat proteins direct protein and membrane trafficking in between early compartments of the secretory pathway in eukaryotic cells. These coat proteins performthe dual, essential tasks of selecting appropriate cargo proteins and deforming the lipid bilayer of appropriate donor membranes into buds and vesicles. COP II proteins are required for selective export of newly synthesized proteins fromthe endoplasmic reticulum (ER). COP I proteins mediate a retrograde transport pathway that selectively recycles proteins fromthe cis-Golgi complex to the ER. Additionally, COP I coat proteins have complex functions in intra-Golgi trafficking and in maintaining the normal structure of the mammalian interphase Golgi complex.
COPI
COPII
COATOMER
GOLGI COMPLEX
COAT PROTEINS