Secondary Metabolites from Chamaedora tepejilote (Palmae)are Active against Mycobacterium tuberculosis
Secondary Metabolites from Chamaedora tepejilote (Palmae)are Active against Mycobacterium tuberculosis
- Phytotherapy Research, 19(4), p.320-322, 2005 .
Due to the emergence of multi-drug resistant Mycobacterium tuberculosis strains, there is an urgent need to search for new antimycobacterial drugs. The present work describes the bioactivity-guided fractionation of Chamaedora tepejilote hexane extract which led to the isolation and the characterization of squalene, farnesol, methylic ester of hexadecanoic acid, â -sitosterol and ursolic acid. Activity against Mycobacterium tuberculosis H37Rv, determined by radiorespirometric Bactec assay, showed ursolic acid, squalene and farnesol to produce a M. tuberculosis growth inhibition of 99
CHAMAEDORA TEPEJILOTE
PALMAE
BIOASSAY-GUIDED ISOLATION
ANTIMYCOBACTERIAL COMPOUNDS
TRITERPENOIDS
URSOLIC ACID
SQUALENE
Due to the emergence of multi-drug resistant Mycobacterium tuberculosis strains, there is an urgent need to search for new antimycobacterial drugs. The present work describes the bioactivity-guided fractionation of Chamaedora tepejilote hexane extract which led to the isolation and the characterization of squalene, farnesol, methylic ester of hexadecanoic acid, â -sitosterol and ursolic acid. Activity against Mycobacterium tuberculosis H37Rv, determined by radiorespirometric Bactec assay, showed ursolic acid, squalene and farnesol to produce a M. tuberculosis growth inhibition of 99
CHAMAEDORA TEPEJILOTE
PALMAE
BIOASSAY-GUIDED ISOLATION
ANTIMYCOBACTERIAL COMPOUNDS
TRITERPENOIDS
URSOLIC ACID
SQUALENE