Formulation and preliminary in vivo dog studies of a novel drug delivery system for the treatment of periodontitis

Formulation and preliminary in vivo dog studies of a novel drug delivery system for the treatment of periodontitis - International Journal of Pharmaceutics, 274(1-2), p.167-183, 2004 .

Anovel drug delivery system for the treatment of periodontitiswas developed using two components. The firstwas tetracycline base loaded into the microtubular excipient halloysite, whichwas coated with chitosan to further retard drug release. Encapsulation efficiencies of 32.5


HALLOYSITE
TETRACYCLINE BASE
CHITOSAN COATING
THERMORESPONSIVE RETENTIVE VEHICLE
PERIODONTITIS TREATMENT