Mucoadhesive chitosan-coated liposomes: characteristics and stability
Mucoadhesive chitosan-coated liposomes: characteristics and stability
- Journal of Microencapsulation, 18(1), p.3-12, 2001 .
Lecithin liposomes, empty or containing FITC-dextran, were prepared by the ethanol injection method. Three diå erent types of chitosans with diå erent molecular weight and degrees of deacetylation were used (Seacure 113, 210 and 311). Chitosan coating was carried out by mixing the liposomal suspension with the chitosan solution followed by incubation. The size of liposomes was measured before and after polymer coating by an image analysis technique. The mean diameter of liposomes containing FITC-dextran was in the size range 250± 280nm, whereas the size after coating was 300± 330 nm, regardless of chitosan type. All chitosan-coated liposomes were of spherical shape and no morphological diå erences between uncoated and coated liposomes were observed. Liposomes with FITC-dextran, originally entrapping 50
MUCOADHESION
LIPOSOMES
CHITOSAN
MUCIN
STABILITY
Lecithin liposomes, empty or containing FITC-dextran, were prepared by the ethanol injection method. Three diå erent types of chitosans with diå erent molecular weight and degrees of deacetylation were used (Seacure 113, 210 and 311). Chitosan coating was carried out by mixing the liposomal suspension with the chitosan solution followed by incubation. The size of liposomes was measured before and after polymer coating by an image analysis technique. The mean diameter of liposomes containing FITC-dextran was in the size range 250± 280nm, whereas the size after coating was 300± 330 nm, regardless of chitosan type. All chitosan-coated liposomes were of spherical shape and no morphological diå erences between uncoated and coated liposomes were observed. Liposomes with FITC-dextran, originally entrapping 50
MUCOADHESION
LIPOSOMES
CHITOSAN
MUCIN
STABILITY