Interpretation of LOD Scores With a Set of Marker Loci
Interpretation of LOD Scores With a Set of Marker Loci
- Genetic Epidemiology, 1(4), p.357-362, 1984 .
The problem discussed is that of interpreting LOD scores when multiple markers are tested for linkage with a particular disease locus. Provided the tests are based on independent segregations, both the maximum and the average LOD can be translated into a score that would have the same significance level were it the result of a single test.
LOD SCORES
MULTIPLE MARKER LOCI
MAXIMUM LOD
AVERAGE LOD
The problem discussed is that of interpreting LOD scores when multiple markers are tested for linkage with a particular disease locus. Provided the tests are based on independent segregations, both the maximum and the average LOD can be translated into a score that would have the same significance level were it the result of a single test.
LOD SCORES
MULTIPLE MARKER LOCI
MAXIMUM LOD
AVERAGE LOD