Omphalotin, A New Cyclic Peptide with Potent Nematicidal Activity from Omphalotus Olearius I. Fermentation and Biological Activity
Omphalotin, A New Cyclic Peptide with Potent Nematicidal Activity from Omphalotus Olearius I. Fermentation and Biological Activity
- Natural Product Letters, 10, p.25-32, 1997 .
Omphalotin (l), a new cyclic peptide possessing strong and selective nematicidal activity against the plant pathogenic Meloidogyne incognita, was isolated from cultures of the basidiomycete Omphalotus olearius together with the antibiotic sesquiterpene illudin M (2)and the inactive 3-(3-indolyl)-Nmethylpropanamide (3). Omphalotin (1)is only weakly active against the saprophytic nematode Caenorhabditis elegans, it is weakly cytotoxic at 100 pg/ml but shows no phytotoxic, antibacterial or antifungal activities. The fermentation of 0. olearius and the production of the metabolites as well as the evaluation of their biological activities are reported.
OMPHALOTUS OLEARIUS
OMPHALOTIN
CYCLOPEPTIDE
3-(3-INDOLYL)-NMETHYLPROPANAMIDE
NEMATICIDAL
MELOIDOGYNE INCOGNITA
CAENORHABDITIS ELEGANS
Omphalotin (l), a new cyclic peptide possessing strong and selective nematicidal activity against the plant pathogenic Meloidogyne incognita, was isolated from cultures of the basidiomycete Omphalotus olearius together with the antibiotic sesquiterpene illudin M (2)and the inactive 3-(3-indolyl)-Nmethylpropanamide (3). Omphalotin (1)is only weakly active against the saprophytic nematode Caenorhabditis elegans, it is weakly cytotoxic at 100 pg/ml but shows no phytotoxic, antibacterial or antifungal activities. The fermentation of 0. olearius and the production of the metabolites as well as the evaluation of their biological activities are reported.
OMPHALOTUS OLEARIUS
OMPHALOTIN
CYCLOPEPTIDE
3-(3-INDOLYL)-NMETHYLPROPANAMIDE
NEMATICIDAL
MELOIDOGYNE INCOGNITA
CAENORHABDITIS ELEGANS