Assessment of acrylic bone cement as a local delivery vehicle for the application of non-steroidal anti-inßammatory drugs
Assessment of acrylic bone cement as a local delivery vehicle for the application of non-steroidal anti-inßammatory drugs
- BioMaterials, 19(1), p.295-301, 1998 .
Non-steroidal anti-inßammatory drugs (NSAIDs)have been widely used to reduce the inßammation and pain in patients su¤ering from arthritis. There is a possible use for these drugs in the treatment of inßammation associated with periodontitis. However, the propensity of NSAIDs to cause serious side e¤ects, including gastrointestinal bleeding, has reduced their usefulness. The local application of NSAIDs can avoid these side e¤ects by delivering low doses of drug directly to the a¤ected site. Three NSAIDs (indomethacin, tolmetin and mefenamic acid)were incorporated into polymethylmethacrylate bone cement (PMMA)strips in a range of concentrations and their cytotoxicity, pattern of drug release and ability to suppress elevated levels of prostaglandin E2 (PGE2)in cultured human peridontal ligament Þbroblasts (HPLF)assessed. The strips released between 10 and 30 percent of the total incorporated drug over 7 days, with the highest levels released by strips containing 20 percent w/w of drug. Strips containing 20 percent indomethacin and mefenamic acid released in excess of toxic levels in the Þrst 24 h. Strips containing 20, 10 and 5 percent w/w NSAID signiÞcantly (P(0.05)reduced the level of PGE2 expression by E. coli lipopolysaccharide (LPS)challenged cells, with only the 20 percent mefenamic acid strip performing signiÞcantly better than the other drugs. We conclude that local d livery of NSAIDs using PMMA as a sustained release vehicle is a possible additional tool in the treatment of periodontitis.
NSAID
PGE2
PERIODONTITIS
LOCAL DELIVERY VEHICLE
Non-steroidal anti-inßammatory drugs (NSAIDs)have been widely used to reduce the inßammation and pain in patients su¤ering from arthritis. There is a possible use for these drugs in the treatment of inßammation associated with periodontitis. However, the propensity of NSAIDs to cause serious side e¤ects, including gastrointestinal bleeding, has reduced their usefulness. The local application of NSAIDs can avoid these side e¤ects by delivering low doses of drug directly to the a¤ected site. Three NSAIDs (indomethacin, tolmetin and mefenamic acid)were incorporated into polymethylmethacrylate bone cement (PMMA)strips in a range of concentrations and their cytotoxicity, pattern of drug release and ability to suppress elevated levels of prostaglandin E2 (PGE2)in cultured human peridontal ligament Þbroblasts (HPLF)assessed. The strips released between 10 and 30 percent of the total incorporated drug over 7 days, with the highest levels released by strips containing 20 percent w/w of drug. Strips containing 20 percent indomethacin and mefenamic acid released in excess of toxic levels in the Þrst 24 h. Strips containing 20, 10 and 5 percent w/w NSAID signiÞcantly (P(0.05)reduced the level of PGE2 expression by E. coli lipopolysaccharide (LPS)challenged cells, with only the 20 percent mefenamic acid strip performing signiÞcantly better than the other drugs. We conclude that local d livery of NSAIDs using PMMA as a sustained release vehicle is a possible additional tool in the treatment of periodontitis.
NSAID
PGE2
PERIODONTITIS
LOCAL DELIVERY VEHICLE