Nanocapsule formation by interfacial polymer deposition following solvent displacement
Nanocapsule formation by interfacial polymer deposition following solvent displacement
- International Journal of Pharmaceutics, 55(1), p.r1-r4, 1989 .
Indomethacin-loaded nanocapsules were prepared by deposition of poly-(D,L-lactide)polymer at the o/w interface following acetone displacement from the oily nanodroplets. An attempt was made to elucidate the mechanism of formation in terms of interracial turbulence between two unequilibrated liquid phases involving flow, diffusion and surface tension decrease (Marangoni effect).
NANOCAPSULE
INDOMETHACIN
POLY-(D,L-LACTIDE)POLYMER
MECHANISM FORMATION
MARANGONI EFFECT
Indomethacin-loaded nanocapsules were prepared by deposition of poly-(D,L-lactide)polymer at the o/w interface following acetone displacement from the oily nanodroplets. An attempt was made to elucidate the mechanism of formation in terms of interracial turbulence between two unequilibrated liquid phases involving flow, diffusion and surface tension decrease (Marangoni effect).
NANOCAPSULE
INDOMETHACIN
POLY-(D,L-LACTIDE)POLYMER
MECHANISM FORMATION
MARANGONI EFFECT