Scale-up in biotechnology
Scale-up in biotechnology
- In Recent Advances in Biotechnology, 210, p.147-182, 1991 .
Scale-up problems are well known and feared in every area of technology, including biotechnology. Solving these problems can be very costly and time consuming, especially when they show up in later stages of process design. In this paper various methods to prevent or solve scale-up problems are presented. In particular attention is paid to the methodology in order to minimize the amount of work necessary. Three levels of problem solving are presented: strategic, tactical and operational. It is shown that this is very convenient in order to use the right tools for the right target in the right way. The emphasis is on scaling down (simulation of full scale conditions at a small scale)because this is generally the only proper way to prevent or solve scale-up problems. The methodology and the use of the tools is demonstrated with the help of two examples.
TIME CONSTANT
STREAM PROCESSING
BUBBLE COLUMN
DIMENSIONLESS GROUP
MECHANISTIC EQUATION
Scale-up problems are well known and feared in every area of technology, including biotechnology. Solving these problems can be very costly and time consuming, especially when they show up in later stages of process design. In this paper various methods to prevent or solve scale-up problems are presented. In particular attention is paid to the methodology in order to minimize the amount of work necessary. Three levels of problem solving are presented: strategic, tactical and operational. It is shown that this is very convenient in order to use the right tools for the right target in the right way. The emphasis is on scaling down (simulation of full scale conditions at a small scale)because this is generally the only proper way to prevent or solve scale-up problems. The methodology and the use of the tools is demonstrated with the help of two examples.
TIME CONSTANT
STREAM PROCESSING
BUBBLE COLUMN
DIMENSIONLESS GROUP
MECHANISTIC EQUATION