In vitro tests for measuring antibacterial activity of toilet soap and detergent bars
In vitro tests for measuring antibacterial activity of toilet soap and detergent bars
- Journal of Pharmaceutical Sciences, 50(10), p.827-830, 1961 .
Two new simple in witro screening tests are described which have proved valuable in predicting the degerming effectiveness of germicidal toilet bars under regular use conditions. The tests, skin disk substantivity and finger imprint tests, measure the residual antibacterial activity of skin treated with soap solutions followed by a water rinse. Thus, a soap germicide is evaluated on the basis of its capacity to become adsorbed to skin and its ability, at low concentrations, to inhibit the growth of bacteria. In witro test data are described on 3,4',~-tribromosalicylanilide and other germicides incorporated into soap and detergent bars. Good correlation between the new in vitro test results and regular hand washing results (serial basinwash test)is achieved.
Two new simple in witro screening tests are described which have proved valuable in predicting the degerming effectiveness of germicidal toilet bars under regular use conditions. The tests, skin disk substantivity and finger imprint tests, measure the residual antibacterial activity of skin treated with soap solutions followed by a water rinse. Thus, a soap germicide is evaluated on the basis of its capacity to become adsorbed to skin and its ability, at low concentrations, to inhibit the growth of bacteria. In witro test data are described on 3,4',~-tribromosalicylanilide and other germicides incorporated into soap and detergent bars. Good correlation between the new in vitro test results and regular hand washing results (serial basinwash test)is achieved.