LncRNAs chaperoning dynamic protein condensates in cancer cells.
LncRNAs chaperoning dynamic protein condensates in cancer cells.
- Molecular Cell, 84(24), 4695-4697, 2024. .
Artículo
In this issue of Molecular Cell, Sun et al. reveal that the long non-coding RNA (lncRNA) DNAJC3-AS1 plays a dual role in maintaining the rRNA processing function of fibrillarin (FBL) in cancer cells. It promotes FBL condensation while preventing abnormal aggregation, offering new therapeutic insights for cancer treatment by targeting lncRNAs involved in the regulation of FBL condensation.
BIOMOLECULAR CONDENSATES
CHROMOSOMAL PROTEINS, NON-HISTONE
GENE EXPRESSION REGULATION, NEOPLASTIC
HUMANS
MOLECULAR CHAPERONES
NEOPLASMS
RNA, LONG NONCODING
RNA, RIBOSOMAL
Artículo
In this issue of Molecular Cell, Sun et al. reveal that the long non-coding RNA (lncRNA) DNAJC3-AS1 plays a dual role in maintaining the rRNA processing function of fibrillarin (FBL) in cancer cells. It promotes FBL condensation while preventing abnormal aggregation, offering new therapeutic insights for cancer treatment by targeting lncRNAs involved in the regulation of FBL condensation.
BIOMOLECULAR CONDENSATES
CHROMOSOMAL PROTEINS, NON-HISTONE
GENE EXPRESSION REGULATION, NEOPLASTIC
HUMANS
MOLECULAR CHAPERONES
NEOPLASMS
RNA, LONG NONCODING
RNA, RIBOSOMAL