Chemical composition, antimicrobial activity, kinetics and mechanism of action of Himalayan-thyme (Thymus linearis Benth.). (Record no. 35670)

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control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625114740.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-1275
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245 10 - TITLE STATEMENT
Title Chemical composition, antimicrobial activity, kinetics and mechanism of action of Himalayan-thyme (Thymus linearis Benth.).
490 0# - SERIES STATEMENT
Volume/sequential designation Journal of Essential Oil Research, 32(1), p.59-68, 2020
520 3# - SUMMARY, ETC.
Summary, etc. In this study, antimicrobial activity of the essential oil (EO)and extracts of Himalayan-thyme (Thymus linearis Benth.)was evaluated against nine pathogenic microbial strains using disc diffusion and microdilution broth assays. The chemical composition of the EO was determined by gas chromatography-flame ionisation detector (GC-FID)and gas chromatography-mass spectrometry (GC-MS). The molecular mechanism of action of the EO was investigated against three pathogenic bacteria (Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis)and three fungal strains (Candida albicans, Candida glabrata, and Candida tropicalis)using the assays of protein leakage, and DNA and RNA leakage through the membrane. Major components of the EO were thymol (54.9 percent), ?-terpinene (16.6 percent)and p- cymene (5.2 percent). The EO showed broad-spectrum potent antibacterial and antifungal activity (MIC 240-990 µg/mL)against test strains. The EO damaged cell membranes and altered cell membrane permeability of test microorganisms. The EO showed a time- and dose-dependent bactericidal and fungicidal effect. It could act as a promising antimicrobial agent due to its short killing time.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element THYMUS LINEAR
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ISLAMIACEAE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ESSENTIAL OIL
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element COMPOSITION ANTIBACTERIAL ACTIVIT
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element YANTIFUNGAL ACTIVITY
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element MECHANISM OF ACTION
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Kumar, A.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Kamal, A.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Singh, S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Padalia, R. C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Tandon, S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Chauhan, A.,
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Verma, R. S.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1VYEnmZe8m1cWRJR7086gWwn4DQ7w-GcH/view?usp=drivesdk">https://drive.google.com/file/d/1VYEnmZe8m1cWRJR7086gWwn4DQ7w-GcH/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-1275 25.06.2025 25.06.2025 Documentos solicitados