Trichostatin A and vorinostat promote adipogenic differentiation through H3K9 acetylation and dimethylation (Record no. 38036)

MARC details
000 -LEADER
fixed length control field 01989nam a2200277Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625122427.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-3657
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 250602s9999 xx |||||s2 |||| ||und|d
245 10 - TITLE STATEMENT
Title Trichostatin A and vorinostat promote adipogenic differentiation through H3K9 acetylation and dimethylation
490 0# - SERIES STATEMENT
Volume/sequential designation Research in veterinary Science, 126, p.207-212, 2019
520 3# - SUMMARY, ETC.
Summary, etc. To explore the effect of epigenetic modification on the differentiation of goat adipose-derived stem cells in vitro, we used two common epigenetic modification inhibitors, trichostatin A and vorinostat, to treat cashmere goat adipose-derived stem cells and induce adipocyte differentiation. The results showed that trichostatin A and vorinostat changed the relative amounts of H3K9 acetylation and dimethylation in the upstream sequence of PPARG, increased peroxisome proliferator-activated receptor gamma (PPARG)transcription before differentiation and then promoted adipocyte differentiation, and regulated the expression of adipocyte-specific genes. We conclude that adipocyte differentiation is regulated dynamically by different histone modifications. The areas of acetylation and demethylation changed by trichostatin A and vorinostat are the basis for further research on the mechanism of PPARG promoter to regulate adipocytes differentiation and provide research theroies for using adipose-derived stem cells as donor to produce transgenic animals to improve meat quality improvement.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ACETYLATION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ADIPOGENIC DIFFERENTIATION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ADIPOSE-DERIVED STEM CELLS
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element DIMETHYLATION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element GOAT
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wang, X.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wang, Z.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wang, Q.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Liang, H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Liu, D.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1S-lPYqOR5vk2dkl2Ba4VZ1RR3w1u5pH2/view?usp=drivesdk">https://drive.google.com/file/d/1S-lPYqOR5vk2dkl2Ba4VZ1RR3w1u5pH2/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-3657 25.06.2025 25.06.2025 Documentos solicitados