Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis (Record no. 39318)

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control field MX-MdCICY
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control field 20250625122450.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-4959
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Title Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis
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Volume/sequential designation FEBS Letters, 508, p.215-220, 2001
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Summary, etc. Geraniol 10-hydroxylase (G10H)is a cytochrome P450 monooxygenase involved in the biosynthesis of iridoid monoterpenoids and several classes of monoterpenoid alkaloids found in a diverse range of plant species. Catharanthus roseus (Madagascar periwinkle)contains monoterpenoid indole alkaloids, several of which are pharmaceutically important. Vinblastine and vincristine, for example, find widespread use as anti-cancer drugs. G10H is thought to play a key regulatory role in terpenoid indole alkaloid biosynthesis. We purified G10H from C. roseus cells. Using degenerate PCR primers based on amino acid sequence information we cloned the corresponding cDNA. The encoded CYP76B6 protein has G10H activity when expressed in C. roseus and yeast cells. The stress hormone methyljasmonate strongly induced G10h gene expression coordinately with other terpenoid indole alkaloid biosynthesis genes in a C. roseus cell culture.
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Personal name Collu, G
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Personal name Unver, N
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Personal name Peltenburg-Looman, A.M.G.
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Personal name Heijen van der, R
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Personal name Verpoorte, R.
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Personal name Memelink, J.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/17belGS5t6gL_QiiRADTIoR_-u3SmwSy9/view?usp=drivesdk">https://drive.google.com/file/d/17belGS5t6gL_QiiRADTIoR_-u3SmwSy9/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-4959 25.06.2025 25.06.2025 Documentos solicitados