COS-1, a putative two-component histidine kinase of Candida albicans, is an in vivo virulence factor (Record no. 40431)

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control field MX-MdCICY
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control field 20250625122510.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-6086
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Title COS-1, a putative two-component histidine kinase of Candida albicans, is an in vivo virulence factor
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Volume/sequential designation Medical Mycology, 39, p.69-74, 2001
520 3# - SUMMARY, ETC.
Summary, etc. The human fungal pathogen, Candida albicans, has three putative histidine kinases showing homology to those of plants, bacteria and other fungi. We have constructed a homozygous deletion strain and a hemizygous reconstituted strain of one of these histidine-kinase-encoding genes, COS-1, in C. albicans. Neither strain showed any growth defect in a number of liquid media nor increased resistance or sensitivity to a number of antifungal drugs. Importantly, we show that the COS-1 homozygous disruption strain had significantly reduced virulence in a systemic murine model of candidosis. Thus, COS-1 appears to be an in vivo virulence factor and may represent a novel target for the development of antifungal drugs.
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Personal name Selitrennikoff, C.P.
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Personal name Alex, L.
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Personal name Miller, T. K.
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Personal name Clemons, K. V.
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Personal name Simon, M. I.
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Personal name Stevens, D. A.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1h1AkSy0F7u2AACQqWer9jQgBCiRWSwUM/view?usp=drivesdk">https://drive.google.com/file/d/1h1AkSy0F7u2AACQqWer9jQgBCiRWSwUM/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-6086 25.06.2025 25.06.2025 Documentos solicitados