fos-1, a putative histidine kinase as a virulence factor systemic aspergillosis (Record no. 40432)

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control field 20250625122511.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-6087
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Title fos-1, a putative histidine kinase as a virulence factor systemic aspergillosis
490 0# - SERIES STATEMENT
Volume/sequential designation Medical Mycology, 40(3), p.259-262, 2002
520 3# - SUMMARY, ETC.
Summary, etc. In fungi, two-component histidine kinases have various functions including regulation of osmosensitivity, and of cell-wall assembly. Furthermore, one of these proteins, cos-1, has been shown to be important for virulence of Candida albicans. Recently, a putative histidine kinase, fos-1, has been isolated and partially characterized from Aspergillus fumigatus. Here we compare the virulence of a fos-1 deletion strain with that of the parental wild-type strain in a murine model of systemic aspergillosis. Our results show that the fos-1 deletion strain has significantly reduced virulence as compared with the parental wild-type strain. Thus, we propose that the fos-1 two-component histidine kinase is a virulence factor of A. fumigatus.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Clemons, K. V.
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Personal name Miller, T. K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Selitrennikoff, C. P.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Stevens, D. A.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1E-6hOCPPr5YmOLu3i1PEOpByM503LYip/view?usp=drivesdk">https://drive.google.com/file/d/1E-6hOCPPr5YmOLu3i1PEOpByM503LYip/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-6087 25.06.2025 25.06.2025 Documentos solicitados