Functional demarcation of the Fusarium core trichothecene gene cluster (Record no. 40531)

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fixed length control field 02079nam a2200289Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625124638.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-6186
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245 10 - TITLE STATEMENT
Title Functional demarcation of the Fusarium core trichothecene gene cluster
490 0# - SERIES STATEMENT
Volume/sequential designation Fungal Genetics and Biology, 41(4), p.454-462, 2004
520 3# - SUMMARY, ETC.
Summary, etc. Many Fusarium species produce toxic sesquiterpenoids known as trichothecenes, including deoxynivalenol and nivalenol by Fusarium graminearum and T-2 toxin by Fusarium sporotrichioides. These toxins are potent inhibitors of protein synthesis and are a significant agricultural problem due to their adverse affect on human, animal, and plant health. Previously, 10-12 co-regulated orthologous genes within a 26-kb region were identified in F. graminearum and F. sporotrichioides, respectively. A majority of these clustered genes have been shown to be involved in different aspects of trichothecene metabolism including 7 of 15 biosynthetic steps. Three other biosynthetic steps are carried out by genes located elsewhere in the genome. In this study, we sequenced 14-16 kb of DNA on both sides of the core clusters and identified 12 new ORFs in both Fusarium species. Although the predicted functions of some of the new ORFs are consistent with some unassigned biochemical reactions, gene expression and gene deletion studies indicate that none are required for trichothecene biosynthesis. These results provide evidence to demarcate both ends of the core trichothecene gene cluster.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element FUNGAL SECONDARY METABOLITE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element PATHOGENIC FUNGI
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element GENE CLUSTER
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element FUSARIUM
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element TRICHOTHECENE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element DON
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Brown, D.W.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Dyer, R.B.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name McCormick, S.P.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Kendra, D.F.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Plattner, R.D.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1lXWnALmBmY_EM-jASO7ALNHbJ48UZHLF/view?usp=drivesdk">https://drive.google.com/file/d/1lXWnALmBmY_EM-jASO7ALNHbJ48UZHLF/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-6186 25.06.2025 25.06.2025 Documentos solicitados