MARC details
| 000 -LEADER |
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| fixed length control field |
02020nam a2200289Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625124641.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-6367 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Substance P-induced activation of p42/44 mitogen-activated protein kinase associated with cell proliferation in human tracheal smooth muscle cells |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Cellular Signalling, 14(11), p.913-923, 2002 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Substance P (SP)released from sensory nerve endings in the airways induces several responses including cell proliferation. However, the mechanisms were not completely understood in tracheal smooth muscle cells (TSMCs). We therefore investigated the effect of SP on cell proliferation and activation of p42/p44 mitogen-activated protein kinase (MAPK)in these cells. SP stimulated [3H]thymidine incorporation and p42/p44 MAPK phosphorylation in a time- and concentration-dependent manner in TSMCs. Both DNA synthesis and phosphorylation of MAPK in response to SP were attenuated by pretreatment with pertussis toxin, genistein, D609, U73122, staurosporine, removal of Ca2+ by BAPTA/AM plus EGTA, PD98059, and SB202190. Furthermore, overexpression of dominant negative mutants, H-Ras-15A and Raf-N4, significantly suppressed p42/p44 MAPK activation induced by SP and PDGF-BB. These results conclude that the mitogenic effect of SP was mediated through the activation of Ras/Raf/MEK/MAPK pathway, which was modulated by PC-PLC, PI-PLC, Ca2+, and PKC in cultured human TSMCs. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CELL PROLIFERATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MAPK |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PROTEIN KINASE C |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
SUBSTANCE P |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
TYROSINE KINASE |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Yang, C-M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Hsiao, L.-D. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Chien, C-S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Lin, C-C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Luo, S-F. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Wang, C-C. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/105JNXk3lOpzeL-OPfHSaKz5owQs5v_gJ/view?usp=drivesdk">https://drive.google.com/file/d/105JNXk3lOpzeL-OPfHSaKz5owQs5v_gJ/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
