Isolation of a Previously Unidentified Polysaccharide (MAR-10)from Hyssop officinalis That Exhibits Strong Activity Against Human Immunodeficiency Virus Type 1 (Record no. 40737)

MARC details
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fixed length control field 01563nam a2200229Ia 4500
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control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625124642.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-6393
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245 10 - TITLE STATEMENT
Title Isolation of a Previously Unidentified Polysaccharide (MAR-10)from Hyssop officinalis That Exhibits Strong Activity Against Human Immunodeficiency Virus Type 1
490 0# - SERIES STATEMENT
Volume/sequential designation BioChemical and Biophysical Research Communications, 210(1), p.145-151, 1995
520 3# - SUMMARY, ETC.
Summary, etc. A polysaccharide (MAR-10)was isolated from the aqueous extract of the plant Hyssop officinalis and examined for its activity against HIV-1 (SF strain)in HUT78 T cell line and primary cultures of peripheral blood mononuclear cells. MAR-10, in a concentration-dependent manner,inhibited HIV-1 replication as demonstrated by the inhibition of HIV-1 p24 antigen and syncytia formation. Furthermore, MAR-10 had no significant direct toxicity or effect on lymphocyte functions or CD4+ and CD8+ T cell counts. In addition, MAR-10 has broad spectrum anti-glycosidase activity. Our study demonstrates that MAR-10 contains strong anti-HIV-1 activity that may be useful in the treatment of patients with HIV-1 infection.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Gollapudi, S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Sharma, H.A.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Aggarwal, S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Byers, L.D.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Ensley, H.E.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Gupta, S.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1iTgTKqxqckgt3-4zDQuIUviLquz41GAk/view?usp=drivesdk">https://drive.google.com/file/d/1iTgTKqxqckgt3-4zDQuIUviLquz41GAk/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-6393 25.06.2025 25.06.2025 Documentos solicitados