Crystal Structure of Negative Cofactor 2 Recognizing the TBP-DNA Transcription Complex (Record no. 40774)

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fixed length control field 01550nam a2200253Ia 4500
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control field MX-MdCICY
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control field 20250625124642.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-6430
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fixed length control field 250602s9999 xx |||||s2 |||| ||und|d
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Title Crystal Structure of Negative Cofactor 2 Recognizing the TBP-DNA Transcription Complex
490 0# - SERIES STATEMENT
Volume/sequential designation Cell, 106(1), p.71-81, 2001
520 3# - SUMMARY, ETC.
Summary, etc. The X-ray structure of a ternary complex of Negative Cofactor 2 (NC2), the TATA box binding protein (TBP), and DNA has been determined at 2.6 A° resolution. The N termini of NC2 a and ß resemble histones H2A and H2B, respectively, and form a heterodimer that binds to the bent DNA double helix on the underside of the preformed TBP-DNA complex via electrostatic interactions. NC2ß contributes to inhibition of TATA-dependent transcription through interactions of its C-terminal a helix with a conserved hydrophobic feature on the upper surface of TBP, which in turn positions the penultimate a helix of NC2ß to block recognition of the TBP-DNA complex by transcription factor IIB. Further regulatory implications of the NC2 heterodimer structure are discussed.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Kamada, K.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Shu, F.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Chen, H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Malik, S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Stelzer, G.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Roeder, R.G.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Meisterernst, M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Meisterernst, M.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/18TkaTCYHbGexUAQhKdYuwmUwR8GwdbvA/view?usp=drivesdk">https://drive.google.com/file/d/18TkaTCYHbGexUAQhKdYuwmUwR8GwdbvA/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-6430 25.06.2025 25.06.2025 Documentos solicitados