NC2 Interacts with BTAF1 and Stimulates Its ATP-Dependent Association with TATA-Binding Protein (Record no. 40889)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 01806nam a2200229Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625124645.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-6548 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | NC2 Interacts with BTAF1 and Stimulates Its ATP-Dependent Association with TATA-Binding Protein |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Molecular and Cellular Biology, 24(22), p.10072-10082, 2004 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Transcriptional activity of the TATA-binding protein (TBP)is controlled by a variety of proteins. The BTAF1 protein (formerly known as TAFII170/TAF-172 and the human ortholog of Saccharomyces cerevisiae Mot1p)and the NC2 complex composed of NC2 (DRAP1)and NC2ß (Dr1)are able to bind to TBP directly and regulate RNA polymerase II transcription both positively and negatively. Here, we present evidence that the NC2 subunit interacts with BTAF1. In contrast, the NC2ß subunit is not able to associate with BTAF1 and seems to interfere with the BTAF1-TBP interaction. Addition of NC2 or the NC2 complex can stimulate the ability of BTAF1 to interact with TBP. This function is dependent on the presence of ATP in cell extracts but does not involve the ATPase activity of BTAF1 nor phosphorylation of NC2. Together, our results constitute the first evidence of the physical cooperation between BTAF1 and NC2 in TBP regulation and provide a framework to understand transcription functions of NC2 and NC2ß in vivo. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Klejman, M.P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pereira, Ll.A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | van Zeeburg, H.J.T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gilfillan, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Meisterernst, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Timmers, H.T.M. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1B2QA3VdenrcU9pRgSsyqVPSLk7Z-HQaW/view?usp=drivesdk">https://drive.google.com/file/d/1B2QA3VdenrcU9pRgSsyqVPSLk7Z-HQaW/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-6548 | 25.06.2025 | 25.06.2025 | Documentos solicitados |