High-throughput RNAi in Caenorhabditis elegans: genome-wide screens and functional genomics (Record no. 40906)

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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-6566
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Title High-throughput RNAi in Caenorhabditis elegans: genome-wide screens and functional genomics
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Volume/sequential designation Differentiation, 72(2-3), p.81-91, 2004
520 3# - SUMMARY, ETC.
Summary, etc. The phenomenon of RNA-mediated interference (RNAi)was first discovered in the nematode Caenorhabditis elegans, in which introduction of double-stranded RNA causes specific inactivation of genes with corresponding sequences. Technical advances in RNAi methodology and the availability of the complete genome sequence have enabled the high-throughput, genome-wide RNAi analysis of this organism. Several groups have used large-scale RNAi to systematically examine every C. elegans gene for knock-down phenotypes, providing basal information to be mined in more detailed studies. Now, in addition to functional genomic RNAi analyses, high-throughput RNAi is also routinely used for rapid, genome-wide screens for genes involved in specific biological processes. The integration of high-throughput RNAi experiments with other large-scale data, such as DNA microarrays and protein-protein interaction maps, enhances the speed and reliability of such screens. The accumulation of RNAi phenotype data dramatically accelerates our understanding of this organism at the genetic level.
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Personal name Sugimoto, A.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1Pf6Ep9D1MXdAhY69r1tUGqZmTUtKyO16/view?usp=drivesdk">https://drive.google.com/file/d/1Pf6Ep9D1MXdAhY69r1tUGqZmTUtKyO16/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-6566 25.06.2025 25.06.2025 Documentos solicitados