Polymers with thiol groups: a new generation of mucoadhesive polymers? (Record no. 40940)
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| fixed length control field | 02183nam a2200193Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625124646.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-6600 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Polymers with thiol groups: a new generation of mucoadhesive polymers? |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Pharmaceutical Research, 16(6), p.876-881, 1999 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | PURPOSE: To improve the mucoadhesive properties of polycarbophil by the introduction of sulfhydryl groups. METHODS: Mediated by a carbodiimide, cysteine was covalently bound to polycarbophil (PCP)forming amide bonds between the primary amino group of the amino acid and the carboxylic acid moieties of the polymer. The amount of covalently attached cysteine and the formation of disulfide bonds within the modified polymer were determined by quantifying the share of thiol groups on the polymer conjugates with Ellman's reagent. The adhesive properties of polycarbophil-cysteine conjugates were evaluated in vitro on excised porcine intestinal mucosa by determining the total work of adhesion (TWA). RESULTS: Depending on the weight-ratio of polycarbophil to cysteine at the coupling reaction, e.g., 16:1 and 2:1, 0.6+/-0.7 micromole and 5.3+/-2.4 micromole cysteine, respectively, were covalently bound per g polymer. The modified polymer displayed improved internal cohesive properties due to the formation of interchain disulfide bonds within the polymer in aqueous solutions at pH-values above 5. Adhesion studies revealed strongly improved adhesive properties. Whereas the TWA was determined to be 104+/-21 microJ for the unmodified polymer, it was 191+/-47 microJ for the polymer-cysteine conjugate 16:1 and 280+/-67 microJ for the polymer-cysteine conjugate 2:1. CONCLUSIONS: Polymers with thiol groups might represent a new generation of mucoadhesive polymers displaying comparatively stronger adhesive properties. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bernkop-Schnurch, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Schwarz, V. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Steininger, S. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1gQ7rt6W-LgutaHQLaRKMEizVWL7MCK_z/view?usp=drivesdk">https://drive.google.com/file/d/1gQ7rt6W-LgutaHQLaRKMEizVWL7MCK_z/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-6600 | 25.06.2025 | 25.06.2025 | Documentos solicitados |