Fabrication of biodegradable polymer scaffolds to engineer trabecular bone. (Record no. 41178)

MARC details
000 -LEADER
fixed length control field 02251nam a2200205Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625124650.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-6840
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 250602s9999 xx |||||s2 |||| ||und|d
245 10 - TITLE STATEMENT
Title Fabrication of biodegradable polymer scaffolds to engineer trabecular bone.
490 0# - SERIES STATEMENT
Volume/sequential designation Journal of BioMaterials Science, Polymer Edition, 7(1), p.23-38, 1995
520 3# - SUMMARY, ETC.
Summary, etc. We present a novel method for manufacturing three-dimensional, biodegradable poly(DL-lactic-co-glycolic acid)(PLGA)foam scaffolds for use in bone regeneration. The technique involves the formation of a composite material consisting of gelatin microspheres surrounded by a PLGA matrix. The gelatin microspheres are leached out leaving an open-cell foam with a pore size and morphology defined by the gelatin microspheres. The foam porosity can be controlled by altering the volume fraction of gelatin used to make the composite material. PLGA 50:50 was used as a model degradable polymer to establish the effect of porosity, pore size, and degradation on foam mechanical properties. The yield strengths and moduli in compression of PLGA 50:50 foams were found to decrease with increasing porosity according to power law relationships. These mechanical properties were however, largely unaffected by pore size. Foams with yield strengths up to 3.2 MPa were manufactured. From in vitro degradation studies we established that for PLGA 50:50 foams the mechanical properties declined in parallel with the decrease in molecular weight. Below a weight average molecular weight of 10,000 the foam had very little mechanical strength (0.02 MPa). These results indicate that PLGA 50:50 foams are not suitable for replacement of trabecular bone. However, the dependence of mechanical properties on porosity, pore size, and degree of degradation which we have determined will aid us in designing a biodegradable scaffold suitable for bone regeneration.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Thomson, R.C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Yaszemski, M.J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Powers, J.M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Mikos, A.G.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1kL9uABwH7hdGpddLKk3ZurrM924GJaZg/view?usp=drivesdk">https://drive.google.com/file/d/1kL9uABwH7hdGpddLKk3ZurrM924GJaZg/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-6840 25.06.2025 25.06.2025 Documentos solicitados