Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway (Record no. 41327)
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| 000 -LEADER | |
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| fixed length control field | 01909nam a2200241Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625124653.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-6990 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Journal of Cell Biology, 170, p.261-272, 2005 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | almitoylation is postulated to regulate Ras signaling by modulating its intracellular trafficking and membrane microenvironment. The mechanisms by which palmitoylation contributes to these events are poorly understood. Here, we show that dynamic turnover of palmitate regulates the intracellular trafficking of HRas and NRas to and from the Golgi complex by shifting the protein between vesicular and nonvesicular modes of transport. A combination of time-lapse microscopy and photobleaching techniques reveal that in the absence of palmitoylation, GFP-tagged HRas and NRas undergo rapid exchange between the cytosol and ER/ Golgi membranes, and that wild-type GFP-HRas and GFP-NRas are recycled to the Golgi complex by a nonvesicular mechanism. Our findings support a model where palmitoylation kinetically traps Ras on membranes, enabling the protein to undergo vesicular transport. We propose that a cycle of depalmitoylation and repalmitoylation regulates the time course and sites of Ras signaling by allowing the protein to be released from the cell surface and rapidly redistributed to intracellular membranes. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Goodwin, J.S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Drake, K.R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rogers, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wright, L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lippincott-Schwartz, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Philips, M.R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kenworthy, A.K. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1JP8TiRlOdh3cckrEFSn4iODF1gdsY7a7/view?usp=drivesdk">https://drive.google.com/file/d/1JP8TiRlOdh3cckrEFSn4iODF1gdsY7a7/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-6990 | 25.06.2025 | 25.06.2025 | Documentos solicitados |