Coatomer-bound Cdc42 regulates dynein recruitment to COPI vesicles (Record no. 41328)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02047nam a2200229Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625124653.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-6991 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Coatomer-bound Cdc42 regulates dynein recruitment to COPI vesicles |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Journal of Cell Biology, 169, p.383-389, 2005 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | ytoskeletal dynamics at the Golgi apparatus are regulated in part through a binding interaction between the Golgi-vesicle coat protein, coatomer, and the regulatory GTP-binding protein Cdc42 (Wu, W.J., J.W. Erickson, R. Lin, and R.A. Cerione. 2000. Nature . 405:800-804; Fucini, R.V., J.L. Chen, C. Sharma, M.M. Kessels, and M. tamnes. 2002. Mol. Biol. Cell . 13:621-631). The precise role of this complex has not been determined. We have analyzed the protein composition of Golgi-derived coat protomer I (COPI)-coated vesicles after activating or inhibiting signaling through co tomerbound Cdc42. We show that Cdc42 has profound effects on the recruitment of dynein to COPI vesicles. Cdc42, C when bound to coatomer, inhibits dynein binding to COPI vesicles whereas preventing the coatomer-Cdc42 interaction stimulates dynein binding. Dynein recruitment was found to involve actin dynamics and dynactin. Reclustering of nocodazole-dispersed Golgi stacks and microtubule/ dynein-dependent ER-to-Golgi transport are both sensitive to disrupting Cdc42 mediated signaling. By contrast, dynein-independent transport to the Golgi complex is insensitive to mutant Cdc42. We propose a model for how proper temporal regulation of motorbased vesicle translocation could be coupled to the completion of vesicle formation. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chen, J-L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fucini, R.V. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lacomis, L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Erdjument-Bromage, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tempst, P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Stamnes, M. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1SvlMIdaelZCwb320ToL0k_i9DZ4OcAjA/view?usp=drivesdk">https://drive.google.com/file/d/1SvlMIdaelZCwb320ToL0k_i9DZ4OcAjA/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-6991 | 25.06.2025 | 25.06.2025 | Documentos solicitados |