A Novel R-Conotoxin Identified by Gene Sequencing Is Active in Suppressing the Vascular Response to Selective Stimulation of Sensory Nerves in Vivo (Record no. 41415)
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| fixed length control field | 02017nam a2200277Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625124654.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-7082 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | A Novel R-Conotoxin Identified by Gene Sequencing Is Active in Suppressing the Vascular Response to Selective Stimulation of Sensory Nerves in Vivo |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | BioChemistry, 42, p.6904-6911, 2003 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | We describe the identification of a conopeptide sequence in venom duct mRNA from Conus Victoriae that suppresses a vascular response to pain in the rat. PCR-RACE was used to screen venom duct cDNAs for those transcripts that encode specific antagonists of vertebrate neuronal nicotinic acetylcholine receptors (nAChRs). One of these peptides, Vc1.1, was active as an antagonist of neuronal nAChRs in receptor binding and functional studies in bovine chromaffin cells. It also suppressed the vascular responses to unmyelinated sensory nerve C-fiber activation in rats. Such vascular responses are involved in pain transmission. Furthermore, its ability to suppress C-fiber function was greater than that of MVIIA, an ö-conotoxin with known analgesic activity in rats and humans. Vc1.1 has a high degree of sequence similarity to the R-conotoxin family of peptides and has the 4,7 loop structure characteristic of the subfamily of peptides that act on neuronal-type nAChRs. The results suggest that neuronal R-conotoxins should be further investigated with respect to their potential to suppress pain. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sandall, D.W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Satkunanathan, N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Keays, D.A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Polidano, M.A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liping, X. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pham, V. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Down, J.G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Down, J.G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Livett, V.G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gayler, K.R. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1K-d7f5arFj91cdtXg0HVG5fNUedEvLz5/view?usp=drivesdk">https://drive.google.com/file/d/1K-d7f5arFj91cdtXg0HVG5fNUedEvLz5/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-7082 | 25.06.2025 | 25.06.2025 | Documentos solicitados |