Different Effects of Some Isoquinoline Alkaloids from Argemone mexicana on Electrically Induced Contractions of Isolated Guinea-pig Ileum (Record no. 41450)

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control field 20250625124655.0
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-7119
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Title Different Effects of Some Isoquinoline Alkaloids from Argemone mexicana on Electrically Induced Contractions of Isolated Guinea-pig Ileum
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Volume/sequential designation Phytotherapy Research, 11(2), p.155-157, 1997
520 3# - SUMMARY, ETC.
Summary, etc. The present study examines the effects of the extracts [petroleum ether, CHCl3, HCl3/MeOH (9:1)and MeOH], partially purified fractions and pure compounds from Argemone mexicana on the electrically induced contractions of the isolated guinea-pig ileum (E.C.I.). The results of the experiments indicate that CHCl3/MeOH (9:1)and MeOH extracts, tested at a concentration of 400, 200 and 100 mg/mL, dose-dependently reduced the guinea-pig ileum contractions, whereas the petroleum ether and CHCl3 extracts did not affect it. Furthermore, the partially purified fractions II-V from the MeOH extract, each tested at concentrations of 200, 100 and 50 mg/mL also inhibited E.C.I. Finally the pure compounds 1-2 (531026-131025-531025 M)isolated and purified from the above fractions significantly reduced, in a dose dependent manner, the electrical contractions of the ileum, whereas compound 3 (531026-13102531025 M)increased them. Since the active compounds 1-3 were respectively identified as protopine, allocryptopine and berberine by NMR, the observed effects could be related mainly to these compounds.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Piacente, S.
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Personal name Capasso, A.
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Personal name De Tommasi, N.
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Personal name Jativa, N.
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Personal name Pizzaw, C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Sorrentino, L.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1pM8h7-seG4Swa1i-oZjvu3siIr2NkC_4/view?usp=drivesdk">https://drive.google.com/file/d/1pM8h7-seG4Swa1i-oZjvu3siIr2NkC_4/view?usp=drivesdk</a>
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-7119 25.06.2025 25.06.2025 Documentos solicitados