Analysis of Molecular Variance Inferred From Metric Distances Among DNA Haplotypes: Application to Human Mitochondrial DNA Restriction Data (Record no. 41767)

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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-7437
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Title Analysis of Molecular Variance Inferred From Metric Distances Among DNA Haplotypes: Application to Human Mitochondrial DNA Restriction Data
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Volume/sequential designation Genetic, 131, p.479-491, 1992
520 3# - SUMMARY, ETC.
Summary, etc. We present here a framework for the study of molecular variation within a single species. Information on DNA haplotype divergence is incorporated into an analysis of variance format, derived from a matrix of squared-distances among all pairs of haplotypes. This analysis of molecular variance (AMOVA)produces estimates of variance components and F-statistic analogs, designated here as @-statisticsr, eflecting the correlation of haplotypic diversitya t different levels of hierarchical subdivision. The method is flexible enough to accommodate several lternative input matrices, corresponding to different types of molecular data, as well as different types of evolutionary assumptions, without modifying the basic structure of the analysis. The significance of the variance components and @-statistics is tested using a permutational approach, eliminating the normality assumption that is conventional for analysis of variance but inappropriate for molecular data. Application of AMOVA to human mitochondrial DNA haplotype data shows that population subdivisions are better resolved when some measure of molecular differences among haplotypes is introduced into the analysis. Att he intraspecific level, howevetrh, e additional information provided by knowing the exact phylogenetic relations among haplotypes or by a nonlinear translation of restriction-site change into nucleotide diversity does not significantly modify the inferred population genetic structure. Monte Carlo studies show that site sampling doesn ot fundamentally affect the significance of the molecular variance components. The AMOVA treatment is easily extended in several different directions and it constitutes a coherent and flexible framework for the statistical analysis of molecular data.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Excoffier, L.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Smouse, P.E.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Quattro, J.M.
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-7437 25.06.2025 25.06.2025 Documentos solicitados