Investigations on Antimycobacterial Activity of Some Ethiopian Medicinal Plants (Record no. 41783)
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| 000 -LEADER | |
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| fixed length control field | 02192nam a2200229Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625124701.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-7454 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Investigations on Antimycobacterial Activity of Some Ethiopian Medicinal Plants |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Phytotherapy Research, 15(4), p.323-326, 2001 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Fifteen crude extracts prepared from seven Ethiopian medicinal plants used to treat various infectious diseases were assessed for their ability to inhibit the growth of Mycobacterium tuberculosis. A preliminary screening of the crude extracts against M. tuberculosis typus humanus (ATCC 27294)was done by dilution assay using Lo¨wenstein-Jensen medium. None of the tested extracts except the acetone fraction obtained from the stem bark of Combretum molle (R. Br. ex G. Don.)Engl & Diels (Combretaceae)showed significant inhibitory action against this strain. The acetone fraction of the stem bark of C. molle caused complete inhibition at concentrations higher than 1 mg/mL. Phytochemical analysis of the bioactive fraction led to the isolation of a major tannin and two oleanane-type pentacyclic triterpene glycosides. The tannin was identified as the ellagitannin, punicalagin, whilst the saponins were characterized as arjunglucoside (also called 4-epi-sericoside)and sericoside. All the pure compounds were further tested against the ATCC strain. Punicalagin was found to inhibit totally growth of the ATCC and also of a patient strain, which was fully sensitive to the standard antituberculosis drugs, at concentrations higher than 600 g/mL and 1.2 mg/mL, respectively. On the other hand, the saponins failed to show any action on the ATCC strain. It appears that our findings are the first report of tannins exhibiting antimycobacterial activity. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Asres, K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bucar, F. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Edelsbrunner, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kartnig, T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Höger, G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Thiel, W. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1S-zcP7XFui9bqh8E4Yo2v6Ss_Ywximo2/view?usp=drivesdk">https://drive.google.com/file/d/1S-zcP7XFui9bqh8E4Yo2v6Ss_Ywximo2/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-7454 | 25.06.2025 | 25.06.2025 | Documentos solicitados |