Antioxidant action of bixin against cisplatin-induced chromosome aberrations and lipid peroxidation in rats (Record no. 41843)

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control field MX-MdCICY
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control field 20250625124702.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-7515
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245 10 - TITLE STATEMENT
Title Antioxidant action of bixin against cisplatin-induced chromosome aberrations and lipid peroxidation in rats
490 0# - SERIES STATEMENT
Volume/sequential designation Pharmacological Research, 43, p.561-566, 2001
520 3# - SUMMARY, ETC.
Summary, etc. Cisplatin is one of the most active cytotoxic agents in the treatment of cancer, but has serious side effects, inducing nephrotoxicity and chromosome aberrations. In this study we evaluated the role of the carotenoid bixin on cisplatin-induced oxidative stress in Wistar rats through three markers of oxidative damage: chromosome aberrations, glutathione depletion and lipid peroxidation. The animals were divided into six treatment groups with six rats in each (n D6). The dose of cisplatin (5.0 mg kg..1 body wt.)was injected i.p. and bixin (2.5 or 5.0 mg kg..1 body wt.)was given by gavage at 48, 24 h and 10 min before the cisplatin injection. The treatment with the highest dose of bixin resulted in a statistically significant reduction, by about 33
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element BIXIN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ANNATTO
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element LIPID PEROXIDATION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CHROMOSOME ABERRATIONS
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Rodrigues Silva, C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Antunes, L.M.G.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Bianchi, L.M.P.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1fs81P6KbRQFtJDh2IV6H8HZUOF9x_rjR/view?usp=drivesdk">https://drive.google.com/file/d/1fs81P6KbRQFtJDh2IV6H8HZUOF9x_rjR/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-7515 25.06.2025 25.06.2025 Documentos solicitados