Interaction of NIMIN1 with NPR1 Modulates PR Gene Expression in Arabidopsis (Record no. 41955)
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| fixed length control field | 02334nam a2200193Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625124704.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-7631 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Interaction of NIMIN1 with NPR1 Modulates PR Gene Expression in Arabidopsis |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Plant Cell, 17, p.1279-1291, 2005 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | The Arabidopsis thaliana NONEXPRESSER OF PR GENES1 (NPR1, also known as NIM1)protein is an essential positive regulator of salicylic acid (SA)-induced PATHOGENESIS-RELATED (PR)gene expression and systemic acquired resistance (SAR). PR gene activity is regulated at the level of redox-dependent nuclear transport of NPR1. NPR1 interacts with members of the TGA family of transcription factors that are known to bind to SA-responsive elements in the PR-1 promoter. In an attempt to identify proteins involved in SA-mediated signal transduction, we reviously described the isolation of three novel genes encoding distinct albeit structurally related proteins designated NIMIN1 (for IM1-INTERACTING1), NIMIN2, and NIMIN3 that interact with NPR1 in the yeast two-hybrid system. Here, we show that NIMIN1 and NPR1 can be copurified from plant extracts, providing biochemical evidence for their interaction. We provide functional evidence for this interaction by describing transgenic plants constitutively expressing high amounts of NIMIN1. These plants show reduced SA-mediated NPR gene induction and a compromised SAR, thus mimicking the described phenotype conferred by npr1. Moreover, they showed reduced RESISTANCE gene-mediated protection. These effects were dependent on the ability of NIMIN1 to interact with NPR1. Mutant plants with a T-DNA insertion in NIMIN1 as well as transgenic plants with reduced NIMIN1 mRNA levels showed hyperactivation of PR-1 gene expression after SA treatment but no effect on the disease resistance phenotype. Our results strongly suggest that NIMIN1 negatively regulates distinct functions of NPR1, providing a mechanism to modulate specific features of SAR. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Weigel, R.R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pfitzner, U.M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gatza, Ch. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1B7s_RpCOfrcSDV7deF9xnSFaPWYcjKnH/view?usp=drivesdk">https://drive.google.com/file/d/1B7s_RpCOfrcSDV7deF9xnSFaPWYcjKnH/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-7631 | 25.06.2025 | 25.06.2025 | Documentos solicitados |