Synthesis and biological evaluation of 4-imidazolylflavans as nonsteroidal aromatase inhibitors (Record no. 42213)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01559nam a2200265Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625124709.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-7900 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis and biological evaluation of 4-imidazolylflavans as nonsteroidal aromatase inhibitors |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Bioorganic Chemistry, 32(6), p.494-503, 2004 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | A series of 4-imidazolylflavans having a variety of substituents on the 2-phenyl ring was synthesized and investigated for their inhibitory effect against aromatase. Structure-activity relationships of these compounds were determined. An additional chlorine atom or a cyano group at the 40 position did not enhance aromatase inhibition as well as a 30-hydroxyl group. The influence of an additional 40-hydroxyl group depends on the substitution pattern of A ring. Among these molecules, 40-hydroxy-4-imidazolyl-7-methoxyflavan is only 2.2-fold less active than the letrozole (as assessed by IC50 values). Letrozole is used as the first-line therapy for metastatic breast cancer. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | 4-IMIDAZOLYLFLAVANS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | BREAST CANCER |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | ANTI-AROMATASE EFFECT |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | STRUCTURE-ACTIVITY RELATIONSHIPS |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pouget, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yahiaoui,S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fagnere, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Habrioux, G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chulia, A.J. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1v6LIwEaRFYSWdICcvmjpPESfy6FTSW97/view?usp=drivesdk">https://drive.google.com/file/d/1v6LIwEaRFYSWdICcvmjpPESfy6FTSW97/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-7900 | 25.06.2025 | 25.06.2025 | Documentos solicitados |