MARC details
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02611nam a2200313Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20250625124711.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-7983 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Intracerebroventricular delivery of dominant negative prion protein in a mouse model of iatrogenic Creutzfeldt-Jakob disease after dura graft transplantation |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
NeuroScience Letters, 402(3), p.222-226, 2006 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
We have developed a novel procedure in which a small collagen sheet (3mm×3 mm)absorbing prion-infected brain homogenates was transplanted onto the brain surface of highly prion-susceptible transgenic mice (Tg(MoPrP)4053/FVB), as an animal model of iatrogenic Creutzfeldt- Jakob disease (iCJD)caused by prion-contaminated cadaveric dura graft transplantation. Using the iCJD model, we further investigated the in vivo efficacy of dominant negative recombinant prion protein with lysine substitution at mouse codon 218 (rPrP-Q218K), which is known to inhibit prion replication in vitro (H. Kishida, Y. Sakasegawa, K. Watanabe, Y. Yamakawa, M. Nishijima, Y. Kuroiwa, N.S. Hachiya, K. Kaneko, Non-glycosylphosphatidylinositol (GPI)-anchored recombinant prion protein with dominant-negative mutation inhibits PrPSc replication in vitro, Amyloid, vol. 11, 2004, pp. 14-20.). Following 7-day intracerebroventricular administration of the rPrP-Q218K via an indwelling catheter connected to the implanted osmotic pump, the median incubation period of Tg(MoPrP)4053/FVB was prolonged considerably from 117 days to 131 days (p = 0.016, log-rank test)in the rPrP-Q218K-treated group, even after a lengthy latency period of as long as 30 days by starting the rPrP-Q218K injection. Whether wild-type rPrP, other mutant rPrPs, or the combination of rPrP-Q218K with other anti-prion compounds might extend the survival period in that condition must be further investigated. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IATROGENIC CREUTZFELDT-JAKOB DISEASE (ICJD) |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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ANIMAL MODEL OF ICJD |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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OSMOTIC PUMP |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
HIGHLY PRION-SUSCEPTIBLE TRANSGENIC MICE (TG(MOPRP)4053/FVB) |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
DOMINANT NEGATIVE RECOMBINANT PRION PROTEIN (RPRP-Q218K) |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Furuya, N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Kawahara, N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Yamakawa, Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Kishida, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Hachiya, N.S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Nishijima, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Kirino, T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Kirino, T. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1W6G9-CG5-1i2ByhLe9u6pL_ddhCz_5vB/view?usp=drivesdk">https://drive.google.com/file/d/1W6G9-CG5-1i2ByhLe9u6pL_ddhCz_5vB/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
