Endogenous targets of RNA-directed DNA methylation and Pol IV in Arabidopsis (Record no. 42405)

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control field 20250625124713.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-8096
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Title Endogenous targets of RNA-directed DNA methylation and Pol IV in Arabidopsis
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Volume/sequential designation The EMBO Journal, 25(12), p.2828-2836, 2006
520 3# - SUMMARY, ETC.
Summary, etc. DRD1 is a SWI/SNF-like protein that cooperates with a plant-specific RNA polymerase, Pol IVb, to facilitate RNA-directed de novo methylation and silencing of homologous DNA. Screens to identify endogenous targets of this pathway in Arabidopsis revealed intergenic regions and plant genes located primarily in euchromatin. Many putative targets are near retrotransposon LTRs or other intergenic sequences that encode short RNAs, which might epigenetically regulate adjacent genes. Consistent with this, derepression of a solo LTR in drd1 and pol IVb mutants was accompanied by reduced cytosine methylation and transcriptional upregulation of neighboring sequences. The solo LTR and several other LTRs that flank reactivated targets are associated with euchromatic histone modifications but little or no H3K9 dimethylation, a hallmark of constitutive heterochromatin. By contrast, LTRs of retrotransposons that remain silent in the mutants despite reduced cytosine methylation lack euchromatic marks and have H3K9 dimethylation. We propose that DRD1 and Pol IVb establish a basal level of silencing that can potentially be reversed in euchromatin, and further reinforced in heterochromatin by other proteins that induce more stable modifications.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element CHROMATIN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element HISTONE METHYLATION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element POL IV
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element RNA-DIRECTED DNA METHYLATION
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element SOLO LTR
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Huettel, B.
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Personal name Kanno, T.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Daxinger, L.
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Personal name Aufsatz, W.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Matzke, A.J.M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Matzke, M.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1NIlBn1IL2cUB5YzP36b_sWAj4pchjvtW/view?usp=drivesdk">https://drive.google.com/file/d/1NIlBn1IL2cUB5YzP36b_sWAj4pchjvtW/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-8096 25.06.2025 25.06.2025 Documentos solicitados