The Arabidopsis Chromatin-Modifying Nuclear siRNA Pathway Involves a Nucleolar RNA Processing Center (Record no. 42407)
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| fixed length control field | 01813nam a2200253Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625124714.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-8098 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | The Arabidopsis Chromatin-Modifying Nuclear siRNA Pathway Involves a Nucleolar RNA Processing Center |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Cell, 126(1), p.79-92, 2006 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | In Arabidopsis thaliana, small interfering RNAs (siRNAs)direct cytosine methylation at endogenous DNA repeats in a pathway involving two forms of nuclear RNA polymerase IV (Pol IVa and Pol IVb), RNA-DEPENDENT RNA POLYMERASE 2 (RDR2), DICER-LIKE 3 (DCL3), ARGONAUTE4 (AGO4), the chromatin remodeler DRD1, and the de novo cytosinemethyltransferase DRM2. We show that RDR2, DCL3, AGO4, and NRPD1b (the largest subunit of Pol IVb)colocalize with siRNAs within the nucleolus. By contrast, Pol IVa and DRD1 are external to the nucleolus and colocalize with endogenous repeat loci. Mutation-induced loss of pathway proteins causes downstream proteins to mislocalize, revealing their order of action. Pol IVa acts first, and its localization is RNA dependent, suggesting an RNA template. We hypothesize that maintenance of the heterochromatic state involves locus-specific Pol IVa transcription followed by siRNA production and assembly of AGO4- and RPD1b-containing silencing complexes within nucleolar processing centers. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pontes, O. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Li, C.F. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Costa Nunes, P. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Haag, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ream, T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Vitins, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jacobsen, S.E. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jacobsen, S.E. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1b-s5_GMIGJtOT_mKCzDNBELtOec043sc/view?usp=drivesdk">https://drive.google.com/file/d/1b-s5_GMIGJtOT_mKCzDNBELtOec043sc/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-8098 | 25.06.2025 | 25.06.2025 | Documentos solicitados |