MARC details
| 000 -LEADER |
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| fixed length control field |
02167nam a2200289Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250625124714.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-8099 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Antiprotozoal and cytotoxic naphthalene derivatives from Diospyros assimilis |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
PhytoChemistry, 67(17), p.1950-1956, 2006 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Chemical investigation of the roots of Diospyros assimilis had led to the isolation and characterization of six naphthalene derivatives, two 2-naphthaldehyes, namely 4-hydroxy-3,5-dimethoxy-2-naphthaldehyde 1, 4-hydroxy-5-methoxy-2-naphthaldehye 2, its related isomer 5-hydroxy-4-methoxy-2-naphthaldehyde 3 and three commonly occurring naphthoquinones, diospyrin 4, 80-hydroxyisodiospyrin 5 and the simple monomer, plumbagin 6. Their chemical structures were established by detailed NMR investigations including 1H and 13C NMR, HSQC, HMBC and NOESY experiments. In addition, the naphthalene derivatives 1-5 were evaluated for their in vitro antiprotozoal activity against protozoan parasites belonging to the genera Trypanosoma, Leishmania and Plasmodium. Among the tested compounds, naphthaldehyde 1 showed moderate inhibition of the growth of the parasites, T. brucei, T. cruzi, L. donovani with IC50 values of 19.82, 12.28 and 38.78 lM and displayed cytotoxicity towards rat skeletal myoblasts (L-6 cells)with IC50 of 174.94 lM, while 2 and 3 were found to be comparatively less active to 1. The dimeric quinones 4 and 5 exhibited good activity against T. brucei and L. donovani with IC50 of 1.12 and 8.82 lM and 12.94 and 16.66 lM respectively. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
DIOSPYROS ASSIMILIS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
EBENACEAE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ANTIPROTOZOAL NAPHTHALENE DERIVATIVES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
NAPHTHALDEHYDES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
NAPHTHOQUINONES |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CYTOTOXICITY |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Ganapaty, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Thomas, P.S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Karagianis, G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Waterman, P.G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Brun, R. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1KjdY-1-GzVOCWVS-kakmXEsbydUuZlES/view?usp=drivesdk">https://drive.google.com/file/d/1KjdY-1-GzVOCWVS-kakmXEsbydUuZlES/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
