Virulence Studies of Aspergillus nidulans Mutants Requiring Lysine or p-Aminobenzoic Acid in Invasive Pulmonary Aspergillosis (Record no. 42485)
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| fixed length control field | 01993nam a2200205Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625124715.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-8179 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Virulence Studies of Aspergillus nidulans Mutants Requiring Lysine or p-Aminobenzoic Acid in Invasive Pulmonary Aspergillosis |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Infection and Immunity, 62, p.5255-5260, 1994 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | To identify steps in fungal intermediary metabolism required by Aspergiflus spp. during invasive pulmonary aspergillosis, we have developed murine models involving Aspergillus nidulans as the inoculum. The advantages of using A. nidulans overAspergillusfiumigatus orAspergilusflavus, which are the most common agents of clinical disease, are the well-understood genetics of A. nidulans and a large range of mutants of this species which are affected in a variety of metabolic pathways. Comparison of the virulence of A. nidulans strains carrying mutations which block the biosynthesis of lysine (lysA2)and p-aminobenzoic acid (pabaAIl)shows that lysA2 strains have reduced virulence while pabaAl strains are entirely nonpathogenic. The pathogenicity ofpabaAI strains can be restored by supplementing the drinking water of animals with p-aminobenzoic acid. The results indicate that the availability of lysine in the lung is limited, and p-aminobenzoic acid is probably not available at all. Thus, models of invasive pulmonary aspergillosis involving A. nidulans can be used to identify metabolic pathways that may be essential for the pathogenicity of A. fiumigatus, the predominant pathogenic species, suggesting potential new targets for antifungal therapy. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | TANG, Ch.M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | SMITH, J.M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | ARST, JR. H.N. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | HOLDEN, D.W. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1xpROdc5Z048x0wQdAQljmGNP2zJRtfcv/view?usp=drivesdk">https://drive.google.com/file/d/1xpROdc5Z048x0wQdAQljmGNP2zJRtfcv/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-8179 | 25.06.2025 | 25.06.2025 | Documentos solicitados |