N6-methyladenine: the other methylated base of DNA (Record no. 42530)

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control field MX-MdCICY
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control field 20250625124716.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-8224
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Title N6-methyladenine: the other methylated base of DNA
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Volume/sequential designation BioEssays, 28(3), p.309-315, 2006
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Summary, etc. Contrary to mammalian DNA, which is thought to contain only 5-methylcytosine (m5C), bacterial DNA contains two additional methylated bases, namely N6-methyladenine (m6A), and N4-methylcytosine (m4C). However, if the main function of m5C and m4C in bacteria is protection against restriction enzymes, the roles of m6A are multiple and include, for example, the regulation of virulence and the control fmanybacterialDNAfunctions such as the replication, repair, expression and transposition of DNA. Interestingly, even if adenine methylation is usually considered a bacterial DNA feature, the presence of m6A has been found in protist and plant DNAs. Furthermore, indirect evidence suggests the presence of m6A in mammal DNA, raising the possibility that this base has remained undetected due to the low sensitivity of the analytical methods used. This highlights the importance of considering m6A as the sixth element of DNA.
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Personal name Ratel, D.
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Personal name Ravanat, J.L.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Berger, F.
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Personal name Wion, D.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1h80YmXCNbuCTbk3iusNwmVnp5AaTBZ8k/view?usp=drivesdk">https://drive.google.com/file/d/1h80YmXCNbuCTbk3iusNwmVnp5AaTBZ8k/view?usp=drivesdk</a>
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-8224 25.06.2025 25.06.2025 Documentos solicitados