Acetophenones with selective antimycobacterial activity (Record no. 42542)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01801nam a2200265Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625124716.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-8236 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Acetophenones with selective antimycobacterial activity |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Letters in Applied MicroBiology, 40(3), p.212-214, 2005 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Mycobacteria are a serious cause of infections in humans, with limited treatment options, as no new antibiotics have been developed against mycobacteria since the 1960s. In this study, the antimycobacterial activity of a small library of acetophenone (AP)compounds was analysed. Methods and Results: Twenty-three AP derivatives were examined for activity against mycobacteria using a microbroth assay. The compounds were bacteriostatic, with the most effective (cyclohexylacetophenone and piperidinoacetophenone)having minimal inhibitory concentrations of 246 lM. Active compounds tended to be more hydrophobic, and may work by alkylation of as yet undetermined intracellular target protein(s). Cytotoxicity against eukaryotic cells was also determined and appears to be unrelated to the bacteriostatic activity. Significance and Impact of the Study: AP may serve as a novel group of useful therapeutics against the mycobacteria. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | CYTOTOXICITY |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MINIMUM BACTERIOCIDAL CONCENTRATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MINIMUM INHIBITORY CONCENTRATION |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MYCOBACTERIUM SMEGMATIS |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rajabi, L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Courreges, C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Montoya, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aguilera, R.J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Primm, T.P. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1W_Ar8dyJ-n1rHS9X67exRgySm4xUtXTs/view?usp=drivesdk">https://drive.google.com/file/d/1W_Ar8dyJ-n1rHS9X67exRgySm4xUtXTs/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-8236 | 25.06.2025 | 25.06.2025 | Documentos solicitados |