A ubiquitin ligase complex assembles linear polyubiquitin chains (Record no. 42552)
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| 000 -LEADER | |
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| fixed length control field | 01851nam a2200277Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625124716.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-8246 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | A ubiquitin ligase complex assembles linear polyubiquitin chains |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | The EMBO Journal, 25(20), p.4877-4887, 2006 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | The ubiquitin system plays important roles in the regulation of numerous cellular processes by conjugating ubiquitin to target proteins. In most ases, conjugation of polyubiquitin to target proteins regulates their function. In the polyubiquitin chains reported to date, ubiquitin monomers are linked via isopeptide bonds between an internal Lys and a C-terminal Gly. Here, we report that a protein complex consisting of two RING finger proteins, HOIL-1L and HOIP, exhibits ubiquitin polymerization activity by recognizing ubiquitin moieties of proteins. The polyubiquitin chain generated by the complex is not formed by Lys linkages, but by linkages between the C- and N-termini of ubiquitin, indicating that the ligase complex possesses a unique feature to assemble a novel head-to-tail linear polyubiquitin chain. Moreover, the complex regulates the stability of Ub-GFP (a GFP fusion protein with an N-terminal ubiquitin). The linear polyubiquitin chain generated post-translationally may function as a new modulator of proteins. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kirisako, T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kamei, K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Murata, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kato, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fukumoto, H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kanie, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sano, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sano, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tanaka, K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Iwai, K. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1_ThPYJUHsWn3xs_70--GH6R5tRNACaLA/view?usp=drivesdk">https://drive.google.com/file/d/1_ThPYJUHsWn3xs_70--GH6R5tRNACaLA/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
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| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-8246 | 25.06.2025 | 25.06.2025 | Documentos solicitados |