Role of Superoxide in Catalase-Peroxidase-Mediated Isoniazid Action against Mycobacteria (Record no. 42576)

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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-8270
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Title Role of Superoxide in Catalase-Peroxidase-Mediated Isoniazid Action against Mycobacteria
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Volume/sequential designation Antimicrobial Agents and Chemotherapy, 42(3), p.709-711, 1998
520 3# - SUMMARY, ETC.
Summary, etc. Isoniazid (INH)activation in vitro is associated with reduction of the mycobacterial ferric KatG catalaseperoxidase by hydrazine and reaction with O2 to form an oxyferrous enzyme complex. Since this complex could also form directly via reaction of ferric KatG with superoxide, intracellular activation might be responsive to superoxide concentration. When Mycobacterium smegmatis carrying the M. bovis katG gene was treated with nontoxic levels of plumbagin, a generator of superoxide, the bacteriostatic activity of INH increased unless a plasmid-borne superoxide dismutase gene was also present. Thus, endogenous superoxide probably contributes to intracellular activation of INH.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Wang, J.Y.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Burger, R.M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Drlica, K.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1QAmpiWeE3yga7re31HIA8Bc_DkLZ529D/view?usp=drivesdk">https://drive.google.com/file/d/1QAmpiWeE3yga7re31HIA8Bc_DkLZ529D/view?usp=drivesdk</a>
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-8270 25.06.2025 25.06.2025 Documentos solicitados