Role of the ABC transporter TruMDR2 in terbinafine, 4-nitroquinoline N-oxide and ethidium bromide susceptibility in Trichophyton rubrum (Record no. 42591)
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| fixed length control field | 01882nam a2200205Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625124717.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-8285 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Role of the ABC transporter TruMDR2 in terbinafine, 4-nitroquinoline N-oxide and ethidium bromide susceptibility in Trichophyton rubrum |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Journal of Medical MicroBiology, 55(8), p.1093-1100, 2006 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | A single-copy gene, designated TruMDR2, encoding an ATP-binding cassette (ABC)transporter was cloned and sequenced from the dermatophyte Trichophyton rubrum. The ORF of TruMDR2 was 4048 nt and the deduced amino acid sequence showed high homology with ABC transporters involved in drug efflux in other fungi. The encoded ABC protein predicted 12 transmembrane segments (TMSs)and two almost identical nucleotide-binding domains (NBDs)arranged in two halves in a (TMS6-NBD)2 configuration and could be classified as a member of the multidrug-resistance (MDR)class of ABC transporters. Northern blot analyses revealed an increased level of transcription of the TruMDR2 gene when mycelium was exposed to acriflavine, benomyl, ethidium bromide, ketoconazole, chloramphenicol, griseofulvin, fluconazole, imazalil, itraconazole, methotrexate, 4-nitroquinoline N-oxide (4NQO)or tioconazole. Disruption of the TruMDR2 gene rendered the mutant more sensitive to terbinafine, 4NQO and ethidium bromide than the control strain, suggesting that this transporter plays a role in modulating drug susceptibility in T. rubrum |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fachin, A.L. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ferreira-Nozawa, M.S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maccheroni, W. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Martinez-Rossi, M.N. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1vGqqC1Q625XpZ73L5rOET6uPnmenIfWU/view?usp=drivesdk">https://drive.google.com/file/d/1vGqqC1Q625XpZ73L5rOET6uPnmenIfWU/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-8285 | 25.06.2025 | 25.06.2025 | Documentos solicitados |