The Tomato NBARC-LRR Protein Prf Interacts with Pto Kinase in Vivo to Regulate Specific Plant Immunity W (Record no. 42601)

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control field MX-MdCICY
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control field 20250625124717.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-8295
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Title The Tomato NBARC-LRR Protein Prf Interacts with Pto Kinase in Vivo to Regulate Specific Plant Immunity W
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Volume/sequential designation The Plant Cell, 18(10), p.2792-2806, 2006
520 3# - SUMMARY, ETC.
Summary, etc. Immunity in tomato (Solanum lycopersicum)to Pseudomonas syringae bacteria expressing the effector proteins AvrPto and AvrPtoB requires both Pto kinase and the NBARC-LRR (for nucleotide binding domain shared by Apaf-1, certain R gene products, and CED-4 fused to C-terminal leucine-rich repeats)protein Prf. Pto plays a direct role in effector recognition within the host cytoplasm, but the role of Prf is unknown. We show that Pto and Prf are coincident in the signal transduction pathway that controls ligand-independent signaling. Pto and Prf associate in a coregulatory interaction that requires Pto kinase activity and N-myristoylation for signaling. Pto interacts with a unique Prf N-terminal domain outside of the NBARCLRR domain and resides in a high molecular weight recognition complex dependent on the presence of Prf. In this complex, both Pto and Prf contribute to specific recognition of AvrPtoB. The data suggest that the role of Pto is confined to the regulation of Prf and that the bacterial effectors have evolved to target this coregulatory molecular switch.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Mucyn, T.S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Clemente, A.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Andriotis, V.M.E.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Balmuth, A.L.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Oldroyd, G.E.D.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Staskawicz, B.J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Rathjena, J.P.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/132Fz_OZXYtRinhLAdpZmYE8RjvbZQDk7/view?usp=drivesdk">https://drive.google.com/file/d/132Fz_OZXYtRinhLAdpZmYE8RjvbZQDk7/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-8295 25.06.2025 25.06.2025 Documentos solicitados