Attenuated Virulence of Uridine-Uracil Auxotrophs of Aspergillus fumigatus (Record no. 42637)

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fixed length control field 01569nam a2200241Ia 4500
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control field MX-MdCICY
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control field 20250625124718.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-8333
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Title Attenuated Virulence of Uridine-Uracil Auxotrophs of Aspergillus fumigatus
490 0# - SERIES STATEMENT
Volume/sequential designation INFECTION AND IMMUNITY, 64(10), p.4401-4405, 1996
520 3# - SUMMARY, ETC.
Summary, etc. Aspergillus fumigatus mutants that are deficient in the de novo UMP biosynthesis pathway because of a mutation in the pyrG gene encoding orotidine-5*-phosphate decarboxylase (and therefore auxotrophic for uridine or uracil)were evaluated in a murine model of invasive aspergillosis. These mutants were entirely nonpathogenic, and mutant conidia remained ungerminated in alveolar macrophages. Both the germination and virulence defects could be restored by supplementing the drinking water of the animals with uridine. DNA-mediated transformation of one of the pyrG mutants with the Aspergillus niger pyrG gene also restored virulence. These results suggest that uridine and uracil are limiting in the lung environment, thus preventing conidium germination and hence virulence of the pyrG mutants.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name D'Enfert, Ch.
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Personal name Diaquin, M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Delit, A.
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Personal name Wuscher, N.
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Personal name Debeaupuis, J.P.
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Personal name Huerre, M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Latge, J.P.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1JJ8O31ODjXfFsX_ObkJ3VZ-kPx-RGZhw/view?usp=drive_link">https://drive.google.com/file/d/1JJ8O31ODjXfFsX_ObkJ3VZ-kPx-RGZhw/view?usp=drive_link</a>
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-8333 25.06.2025 25.06.2025 Documentos solicitados