Synergistic antimycobacterial activities of sesquiterpene lactones from Laurus spp. (Record no. 42801)

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control field 20250625124721.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-8497
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Title Synergistic antimycobacterial activities of sesquiterpene lactones from Laurus spp.
490 0# - SERIES STATEMENT
Volume/sequential designation Journal of Antimicrobial Chemotherapy, 59(3), p.548-552, 2007
520 3# - SUMMARY, ETC.
Summary, etc. Objectives: The aim of this study was to determine the antimycobacterial potential of laurel oil, its fractions and its two sesquiterpene lactones against several mycobacterial strains and clinical isolates, and to establish the possibility of occurrence of some synergistic effects between those lactones using a modification of the fluorometric Alamar Blue microassay (FMABA). Methods: The in vitro antimycobacterial activity of whole oil and its fractions and pure active compounds were determined by FMABA. A bioassay-guided fractionation of the traditional preparation of laurel oil from Madeira Islands was performed, yielding pure compounds chemically identified by standard procedures. Synergism of pure compounds was established by X/Y quotient analysis adapted to FMABA. Results: Sesquiterpene lactones, costunolide and ehydrocostuslactone, were the compounds responsible for the antimycobacterial activity against Mycobacterium tuberculosis H37Rv with MICs of 6.25 and 12.5 mg/L, respectively. Antimycobacterial activity against drug-resistant M. tuberculosis clinical isolates was better for the mixture than for pure compounds. Conclusions: Both lactones presented synergistic activity, i.e. analysis of relative fluorescence units presented an X/Y value <0.5 at a concentration of 1/8 MIC of each compound in the combination. Establishment of synergism by FMABA represents another application of the microplate Alamar Blue assay.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element COSTUNOLIDE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element DEHYDROCOSTUSLACTONE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ALAMAR BLUE
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element SYNERGISM
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Luna-Herrera, J.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Costa, M.C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name González, H.G.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Rodrigues, A.I.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Castilho, P.C.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1kerB4F3lezZilLd79CLovdU9iMDTKTHK/view?usp=drivesdk">https://drive.google.com/file/d/1kerB4F3lezZilLd79CLovdU9iMDTKTHK/view?usp=drivesdk</a>
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