MARC details
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01779nam a2200241Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20250625124725.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-8681 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Nature Immunology, 8, p.514-521, 2007 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
Antigen receptor-mediated production of inositol-1,4,5-trisphosphate (Ins(1,4,5)P3)in lymphocytes triggers the release of Ca2+ from intracellular stores; this release of Ca2+ results in the opening of store-operated Ca2+ channels in the plasma membrane. Here we report that mice lacking Ins(1,4,5)P3 3-kinase B (Itpkb), which converts Ins(1,4,5)P3 to inositol-1,3,4,5- tetrakisphosphate (Ins(1,3,4,5)P4), had impaired B lymphocyte development and defective immunoglobulin G3 antibody responses to a T lymphocyte-independent antigen. Itpkb-deficient B lymphocytes had the phenotypic and functional features of tolerant B lymphocytes and showed enhanced activity of store-operated Ca2+ channels after B lymphocyte receptor stimulation which was reversed by the provision of exogenous Ins(1,3,4,5)P4. Our data identify Itpkb and its product Ins(1,3,4,5)P4 as inhibitors of store-operated Ca2+ channels and crucial regulators of B cell selection and activation. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Miller, A.T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Sandberg, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Huang, Y.H. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Young, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Sutton, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Sauer, K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Cooke, M.P. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1AYqjXQ4yE-DLzvr_jDAlztsG89TPfrTn/view?usp=drivesdk">https://drive.google.com/file/d/1AYqjXQ4yE-DLzvr_jDAlztsG89TPfrTn/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
