Antileishmanial activity, cytotoxicity and QSAR analysis of synthetic dihydrobenzofuran lignans and related benzofurans (Record no. 43124)
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| fixed length control field | 01760nam a2200241Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625124728.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-8845 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Antileishmanial activity, cytotoxicity and QSAR analysis of synthetic dihydrobenzofuran lignans and related benzofurans |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Bioorganic & Medicinal Chemistry, 13(3), p.661-669, 2005 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Abstract-A series of synthetic dihydrobenzofuran lignans and related benzofurans were evaluated for their cytotoxicity in a screening panel consisting of various human tumour cell lines, and for their antiprotozoal activity against L. donovani (axenic amastigotes), chloroquine resistant Plasmodium falciparum (strain K1), Trypanosoma brucei rhodesiense and T. cruzi, and for cytotoxicity on L6 cells. No promising cytotoxicities against human tumour cell lines were observed for newly synthesised compounds, but the dimerisation product of some lipophylic esters of caffeic acid, such as compound 2g, showed a high activity against chloroquine-resistant P. falciparum (strain K1)(IC50 0.43lg/mL)and L. donovani (axenic amastigotes)(IC50 0.12lg/mL), which was confirmed in an infected macrophage assay (IC50 0.19lg/mL). QSAR models for the cytotoxic and antileishmanial activity were generated using Quasar receptor surface modelling. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Van Miert, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Van Dyck, S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Schmidt, T.J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Brund, R. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Vlietinck, A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lemiereb, G. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pietersa, L. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1zeEgdF1WhqvA6Hk7xUEvJ4XuzA3U7ojc/view?usp=drivesdk">https://drive.google.com/file/d/1zeEgdF1WhqvA6Hk7xUEvJ4XuzA3U7ojc/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-8845 | 25.06.2025 | 25.06.2025 | Documentos solicitados |